An improved technique for experimental infections with skin penetrating nematode larvae (Necator americanus)
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چکیده
منابع مشابه
An improved method for nematode infection assays in Drosophila larvae
The infective juveniles (IJs) of entomopathogenic nematodes (EPNs) seek out host insects and release their symbiotic bacteria into their body cavity causing septicaemia, which eventually leads to host death. The interaction between EPNs and their hosts are only partially understood, in particular the host immune responses appears to involve pathways other than phagocytosis and the canonical tra...
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متن کاملNecator americanus (human hookworm) aspartyl proteinases and digestion of skin macromolecules during skin penetration.
The infective larvae of Necator americanus were shown to secrete all mechanistic classes of proteolytic enzymes with two overall pH optima of 6.5 and 8.5 using fluorescein isothiocyanate-labeled casein as the substrate. Since infective larvae are obligate skin penetrators, the effect of each of these enzyme classes against macromolecules derived from human skin was examined. Larval secretions w...
متن کاملThe physicochemical fingerprint of Necator americanus
Necator americanus, a haematophagous hookworm parasite, infects ~10% of the world's population and is considered to be a significant public health risk. Its lifecycle has distinct stages, permitting its successful transit from the skin via the lungs (L3) to the intestinal tract (L4 maturing to adult). It has been hypothesised that the L3 larval sheath, which is shed during percutaneous infectio...
متن کاملNecator americanus and Helminth Co-Infections: Further Down-Modulation of Hookworm-Specific Type 1 Immune Responses
BACKGROUND Helminth co-infection in humans is common in tropical regions of the world where transmission of soil-transmitted helminths such as Ascaris lumbricoides, Trichuris trichiura, and the hookworms Necator americanus and Ancylostoma duodenale as well as other helminths such as Schistosoma mansoni often occur simultaneously. METHODOLOGY We investigated whether co-infection with another h...
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ژورنال
عنوان ژورنال: International Journal for Parasitology
سال: 1986
ISSN: 0020-7519
DOI: 10.1016/0020-7519(86)90080-9